The Apocolypse has been postponed
I've got the idea for a game based loosely on a combination of High School of the Dead and Soul Eater. The basic premise is that a biological (or magical) attack has been unleashed on this smallish island; perhaps a government test gone wrong or simply a fated event.
It turns out that the seemingly ordinary school has a secret: a small number of students are trained in dealing with just such a threat. Maybe some of them are monster hunters, like Van Helsing (the movie). Others are trained as mystics or hunters (like Soul Eater).
I don't feel confident in my ability at present to run such a game but I see it as similar to High School of the Dead, only the cast might be teachers or other staff members.