For folks interested in more info:
https://en.wikipedia.org/wiki/Marvel_1602 :)
I have played in a MSH-FASERIP medieval supers type of campaign, where the supers had to be cautious about overt displays of power, lest they be targeted by the Inquisition... :o
Having that wrinkle on top of the usual good guys trying to stop the bad guys, and with the refreshing change-of-pace setting, made a very enjoyable campaign.
I haven't played DnD since v3.5, but if the newfangled version is similar, it might be tricky to build some types of supers. For example, how would you build a teleporter like Nightcrawler in DnD5 or PF? Supers often have a narrow focus for powers (such as being an excellent teleporter, but without other powers)...
If I was able to build a super rather than a fantasy character, I would be very interested in a medieval supers campaign. :)