All three are quite okay, I think. I suppose a Galactica -style game might work, really. Or, one could go for the Homeworld-series (
http://homeworld.wikia.com) style with the characters being crew and passengers of a great Arc-style ship, trying to survive the extinction of their own species, either against some kind of an apocalypse that met their homeworld or an enemy chasing them.
As for the races, we could go for all-human or at least humanlike creatures (at least to begin with).
Mecha, starfighters, why not.
What were you planning on using for rules or would this be a freeform game?