Genesys?
With Genesys in the wild, and being out for a bit now, I would love to see someone run a game with a modern-day setting. Whether a Heist (Leverage-style), Spy (Bond, Bourne), or Military (Navy Seals, etc. ) any I think would be a blast. :)
Although, with Realms of Terrinoth coming, Fantasy setting might be interesting too...