I'd like to find a game that similar to Rune Story. Focusing on the crafting and creation of new items/weapons/magic. I'm fine with a larger plot but I doubt something as epic as save the world would be realistic when focusing on the shop or lab my character would own/operate.

Any system that I can learn is fine by me.

I might be interested in running such a game.  My current fantasy system of choice is D&D 5e.  Do you have any issue with that?

I'd be interested in this as well