I'm interested in playing a World of the Dead game to learn Savage Worlds properly. Zombie apocalypses are among my favorites, so I want to definitely play around with the domain creation and survival rules. It's easy, self-sustaining, and offers lots of great imagery and roleplaying hooks.

Destiny would be another fun setting to play around in, based on the Bungie game of the same name. We get to play as cool Guardians doing Guardian things in the solar system, fighting to push back the Darkness. In lieu of this, I would also accept Mass Effect, all the more so if we got to play characters somewhat more capable than starting level.

Aliens or Aliens vs Predator would be fun. Something set in the future, probably post-Aliens, ignoring all other movies but the first two and maybe drawing a little on EU stuff. Emphasize mystery, tension, and horror in an attempt to survive on a distant colony world, or maybe some far-flung planet outside regulated space where clandestine experiments unfold.