Building a Cyberpunk Baltimore
If you're familiar with Baltimore, you probably know all this, but...
With Johns Hopkins and Loyola and UMed, among others, you have a great base for academic/technical knowledge and/or sinister laboratories. A lot of the MD state government agencies are headquartered in Balto, although the state capitol is Annapolis.
Amid the state office complex on Preston Street is a great early-20th century National Guard Armory, built like a castle. Vast swaths of parkland abound and a good-sized zoo. Camden Yards and the Ravens stadium are down by the Inner Harbor, not to mention a very large industrial/shipping area. Not to mention Fort McHenry.
Not too far away in Frederick is Fort Detrick, long the center for US Army research into bioweapons.