IC: Mass Effect D20
Mass Effect? Yes, absolutely! I love the setting. All the more so if you just sort of rewrite the ending of ME3 so that the weapon just wipes out the Reapers and not all life/completely undoes all the work we put into that setting. The reason I recommend that is because it leaves things so much more open and interesting: the Genophage solved, the Geth have their own individuality and are free to seek out a purpose as an entirely new race of sentient beings, and you can explore the conflict and challenges in rebuilding a galaxy.
Mass Effect is amazing. My second-favorite sci-fi setting, I think! I'd be down to play whatever system you choose. D20 is okay (the core engine is just not that great), but I've statted up Mass Effect in Mutants & Masterminds, Tri-Stat 3E/4E (which would be my recommendation), and others. It's all pretty easy. If you wanna give it a go, with any system, or want input on how to make other stuff work, please let me know.
Best wishes for a speedy recovery! If only we had a Mordin here....